Target intelligence / Profile preview

Cytochrome P450 Family 51 (CYP51)

Target: CYP51
Molecular classification: Enzyme, Cytochrome P450, Monooxygenase

Overview

The CYP51 family, also known as cytochrome P450 family 51 or sterol 14α-demethylase, is a highly conserved group of enzymes found across animals, fungi, and plants. These enzymes play a critical role in the biosynthesis of sterols by catalyzing the demethylation of lanosterol and related molecules—a key step in producing cholesterol and other essential sterols. It is a major drug target for antifungal drugs such as azoles.

Other names: Sterol 14α-demethylaseP45014DMCYP51A1

Mechanism of action

Inhibition of fungal CYP51

Biological functions

Sterol biosynthesisCholesterol synthesisErgosterol synthesisC14-demethylation

Disease associations

InfectionOther

Interacting drugs

Azoles

Beyond the preview

Go deeper on Cytochrome P450 Family 51 (CYP51).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cytochrome P450 Family 51 (CYP51).

Explore the full profile