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Target intelligence / Profile preview
Cytochrome P450 family 51 subfamily A member 1 (CYP51A1)
- Target
- CYP51A1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
CYP51A1 is a monooxygenase enzyme belonging to the cytochrome P450 superfamily. It catalyzes the 14α-demethylation of lanosterol, a crucial step in the biosynthesis of cholesterol in animals, ergosterol in fungi, and other sterols in plants. This enzyme is highly conserved across eukaryotes and is a major target for antifungal drugs (azole antifungals) that disrupt ergosterol production in fungi. In humans, mutations or dysregulation can impact cholesterol synthesis, and it has been explored as a target for herbicides and cholesterol-lowering agents.
- Other names
- Lanosterol 14α-demethylaseSterol 14-demethylase
02
Mechanism of action
Inhibition of fungal CYP51 by binding to its heme group active site as a noncompetitive inhibitor, disrupting ergosterol production.
03
Biological functions
Sterol biosynthesisCholesterol synthesisErgosterol synthesisLipid metabolismRegulation of membrane structure and function
04
Disease associations
InfectionDysregulation of cholesterol synthesis
05
Safety considerations
Development of resistance through gene mutations or overexpression mechanisms within pathogens.Potential impact on cholesterol synthesis in humans.
06
Interacting drugs
Miconazole
2 more in the full profile.
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