Cytochrome P450 family 51 subfamily A member 1 pseudogene 1 (CYP51A1P1)

Cytochrome P450 family 51 subfamily A member 1 pseudogene 1 (CYP51A1P1) is a pseudogene related to the CYP51A1 gene, which encodes the functional enzyme cytochrome P450 51A1 involved in sterol biosynthesis (specifically in the demethylation of lanosterol during the production of cholesterol and other sterols). However, CYP51A1P1, as a pseudogene, has accumulated mutations—such as premature stop codons or frameshifts—that prevent it from encoding a functional protein product. As with most human pseudogenes, it is not expressed as a functional protein and plays no direct role in cellular physiology, therapeutic intervention, or disease etiology. Pseudogenes can sometimes regulate their parent genes through various RNA-based mechanisms (e.g., as competitive endogenous RNAs), but there are no reports or evidence indicating such a function for CYP51A1P1 specifically. In summary, CYP51A1P1 is a nonfunctional pseudogene and is not a relevant target in the context of drug discovery, receptor pharmacology, or enzyme inhibition. If your focus is on the functional enzyme in sterol metabolism, the correct target is "Cytochrome P450 family 51 subfamily A member 1" (CYP51A1), not the pseudogene CYP51A1P1.

Other names

CYP51 pseudogeneCYP51A pseudogene

Not applicable.