Target intelligence / Profile preview

Cytochrome P450 Family Enzymes (CYP)

Target: CYP
Molecular classification: Enzyme, Monooxygenase, Heme-thiolate protein

Overview

Cytochrome P450 enzymes (CYPs) are a large superfamily of heme-containing monooxygenases involved in the metabolism of a wide range of endogenous and exogenous compounds. They play a crucial role in drug metabolism, steroid hormone biosynthesis, and detoxification processes. Genetic polymorphisms in CYP genes can lead to inter-individual differences in drug response and toxicity. Some CYP isoforms are therapeutic targets for diseases involving steroid hormone imbalances or other metabolic disorders.

Other names: P450sCYPs

Mechanism of action

Monooxygenation/hydroxylation of substrates, leading to altered biological activity or increased excretability.

Biological functions

Drug metabolismXenobiotic metabolismSteroid hormone biosynthesisCholesterol metabolismBile acid synthesisVitamin D metabolismEicosanoid metabolismRetinoic acid metabolismDetoxification

Disease associations

CancerEndocrine disordersMetabolic disordersDrug toxicityCardiovascular disease

Safety considerations

Drug-drug interactions (due to CYP inhibition or induction)Genetic polymorphisms affecting CYP activity (leading to variable drug response)CYP-mediated drug toxicityOff-target effects

Interacting drugs

Aromatase inhibitors

3 more in the full profile.

Biomarkers

CYP genotype (for predicting drug response)CYP enzyme activity (for assessing drug metabolism)

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