Target intelligence / Profile preview

Cytochrome P450 family enzymes – subfamily 3 member A4 (CYP3A4)

Target: CYP3A4
Molecular classification: Enzyme, Heme-thiolate monooxygenase, Cytochrome P450

Overview

CYP3A4 is a highly versatile enzyme essential for human drug metabolism, influencing both efficacy and safety profiles through its broad substrate range and susceptibility to induction/inhibition by various agents. It is a key member of the cytochrome P450 superfamily, primarily responsible for the metabolism of a wide range of xenobiotics and endogenous compounds.

Other names: CP33CP34CYP3ACYP3A3CYPIIIA3CYPIIIIA4HLPNF‐25P450C3P450PCN1

Mechanism of action

Monooxygenase; catalyzes oxidation reactions to facilitate drug excretion. Alters drug concentrations through induction or inhibition of its activity.

Biological functions

Drug metabolismXenobiotic metabolismSteroid hormone synthesis/terminationBile acid detoxificationFatty acid metabolismMonooxygenase activityCarcinogen activation/inactivation

Disease associations

Drug-drug interactionsPharmacokinetic variabilityAdverse drug reactionsTherapeutic failure

Safety considerations

Drug-drug interactions due to CYP3A4 inhibition or induction leading to altered drug plasma concentrations and potential toxicity or therapeutic failure.Genetic polymorphisms can affect CYP3A4 activity.

Interacting drugs

Acetaminophen (paracetamol)

7 more in the full profile.

Beyond the preview

Go deeper on Cytochrome P450 family enzymes – subfamily 3 member A4 (CYP3A4).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cytochrome P450 family enzymes – subfamily 3 member A4 (CYP3A4).

Explore the full profile