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Target intelligence / Profile preview
Cytochrome P450 Oxidoreductase (POR)
- Target
- POR
- Molecular classification
- Enzyme, Oxidoreductase, Flavoprotein
01
Overview
Cytochrome P450 oxidoreductase (POR) is a membrane-bound enzyme essential for electron transfer from NADPH to microsomal cytochromes P450 and other heme proteins. It plays a central role in drug metabolism, steroid synthesis, and other critical biological processes. Mutations can lead to severe developmental and metabolic disorders.
- Other names
- CPRCYPORNADPH-cytochrome P450 reductasecytochrome p450 reductase
02
Mechanism of action
Facilitates electron transfer from NADPH to cytochromes P450 and other heme-containing proteins.
03
Biological functions
Electron transferDrug metabolismSteroid hormone biosynthesisCholesterol/fatty acid homeostasisRedox reactions
04
Disease associations
Antley-Bixler syndromeCongenital malformation syndromesMetabolic disorders
05
Safety considerations
Mutations can cause severe developmental and metabolic disorders.Complete loss is embryonic lethal.
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