Molecular Classification
Enzyme, Oxidoreductase, Flavoprotein
Other Names
CPR, CYPOR, NADPH-cytochrome P450 reductase, cytochrome p450 reductase
Disease Roles
Antley-Bixler syndromeCongenital malformation syndromesMetabolic disorders

Cytochrome P450 Oxidoreductase Overview

Cytochrome P450 oxidoreductase (POR) is a membrane-bound enzyme essential for electron transfer from NADPH to microsomal cytochromes P450 and other heme proteins. It plays a central role in drug metabolism, steroid synthesis, and other critical biological processes. Mutations can lead to severe developmental and metabolic disorders.

Mechanism of Action

Facilitates electron transfer from NADPH to cytochromes P450 and other heme-containing proteins.

Biological Functions

Electron transfer
Drug metabolism
Steroid hormone biosynthesis
Cholesterol/fatty acid homeostasis
Redox reactions

Disease Associations

Antley-Bixler syndrome
Congenital malformation syndromes
Metabolic disorders

Safety Considerations

  • Mutations can cause severe developmental and metabolic disorders.
  • Complete loss is embryonic lethal.