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Target intelligence / Profile preview
Cytochrome P450 Sterol 14α-Demethylase (CYP51)
- Target
- CYP51
- Molecular classification
- Enzyme, Cytochrome P450, Heme protein
01
Overview
Cytochrome P450 sterol 14α-demethylase (CYP51) is a highly conserved enzyme belonging to the cytochrome P450 superfamily. It catalyzes the oxidative removal of the 14α-methyl group from sterol precursors in the sterol biosynthetic pathway, a crucial step in the production of sterols like ergosterol (in fungi), phytosterols (in plants), and cholesterol (in animals). CYP51 is a significant drug target for antifungal medications, particularly azoles, which inhibit the enzyme and disrupt fungal membrane integrity. It is one of the most widely distributed P450 enzymes.
- Other names
- Sterol 14α-demethylaseCYP51A1
02
Mechanism of action
Inhibition of sterol 14α-demethylase, leading to disruption of fungal membrane integrity and function
03
Biological functions
Sterol biosynthesisErgosterol biosynthesisCholesterol biosynthesisPhytosterol biosynthesis
04
Disease associations
Infection
05
Safety considerations
Drug resistanceOff-target effects of azole antifungals
06
Interacting drugs
Azole antifungals
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