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Cytokeratin

Molecular classification: Intermediate filament protein

Overview

Cytokeratins are a family of intermediate filament proteins found in epithelial cells. They provide structural support, maintain cell shape and polarity, and protect tissues from mechanical stress. Different epithelia express distinct cytokeratin patterns, making them valuable biomarkers for tissue identification and cancer diagnosis. They are not typically direct therapeutic targets, but their expression patterns are critical for diagnostic and prognostic purposes.

Mechanism of action

N/A

Biological functions

Structural supportCell shape maintenanceMechanical stress resistanceCell polarity maintenanceStress responseWound healingApoptosis regulationCell cycle regulation

Disease associations

CancerGenetic disorders (related to mutations)

Biomarkers

Cancer diagnosisCancer subtypingMesothelioma diagnosis (CK5/6)

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