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Target intelligence / Profile preview
Cytokine-Induced Killer Cell (CIK cell)
- Target
- CIK cell
- Molecular classification
- Immune effector cell, Lymphocyte
01
Overview
Cytokine-induced killer (CIK) cells are a heterogeneous population of immune effector cells that display both T-cell and natural killer (NK) cell-like phenotypes. They are generated by ex vivo incubation of human peripheral blood mononuclear cells (PBMCs) or cord blood mononuclear cells with specific cytokines, including interferon-gamma (IFN-γ), anti-CD3 antibody, recombinant human interleukin-1 (IL-1), and recombinant human interleukin-2 (IL-2). CIK cell therapy is being explored primarily in cancer immunotherapy due to their broad-spectrum antitumor activity and ease of expansion.
- Other names
- CIKCytokine induced killer cells
02
Mechanism of action
MHC-unrestricted cytotoxicity; perforin/granzyme & FasL pathways
03
Biological functions
CytotoxicityImmune responseTumor cell lysisCytokine secretion
04
Disease associations
Cancer
05
Safety considerations
Lack of fine-tuned specificity compared to engineered CAR-T approachesPotential off-target effects
06
Interacting drugs
Interferon-gamma
4 more in the full profile.
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