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Target intelligence / Profile preview
Cytokine-inducible SH2-containing protein (CISH)
- Target
- CISH
- Molecular classification
- Suppressor Of Cytokine Signaling, SOCS family protein
01
Overview
Cytokine-inducible SH2-containing protein (CISH) is a member of the suppressor of cytokine signaling (SOCS) family. It acts as an inducible inhibitor of cytokine signaling, negatively regulating T cell receptor (TCR) signaling and natural killer (NK) cell cytotoxicity. Dysregulation of CISH is linked to various diseases, including infections, asthma, anemia, and cancer. Targeting CISH enhances the efficacy of adoptive T-cell and NK cell therapies against tumors.
- Other names
- CISSTAT-induced STAT inhibitor
02
Mechanism of action
Inhibition of CISH enhances T cell and NK cell activity against tumors. Targeting CISH in NK cells improves ex vivo proliferation and limits NK cell exhaustion, impairing primary tumor and metastasis development.
03
Biological functions
Negative regulation of cytokine signalingRegulation of T cell receptor signalingRegulation of NK cell cytotoxicityRegulation of erythropoiesisImmune response
04
Disease associations
BacteremiaTuberculosisMalariaBronchial asthmaMacrocytic anemiaCancer
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