Molecular Classification
Receptor, Type I cytokine receptor
Other Names
CD132, Interleukin-2 Receptor Subunit Gamma, IL-2RG, Common Gamma Chain
Disease Roles
X-linked Severe Combined Immunodeficiency (X-SCID)Immunodeficiency

Cytokine Receptor Common Subunit Gamma Overview

The cytokine receptor common subunit gamma (γc), also known as CD132 or IL-2RG, is a critical component of the immune system. It is a shared receptor subunit for multiple interleukin receptors (IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21), influencing lymphocyte development, growth, differentiation, and survival. Mutations in the gene encoding this chain cause X-linked severe combined immunodeficiency disease (X-SCID).

Mechanism of Action

Modulation of cytokine signaling

Biological Functions

Lymphocyte development
Lymphocyte growth
Lymphocyte differentiation
Lymphocyte survival
Signal transduction
Immune response

Disease Associations

X-linked Severe Combined Immunodeficiency (X-SCID)
Immunodeficiency

Safety Considerations

  • Potential for immune dysregulation when targeted therapeutically.