Cytokine receptors for IL-6, IL-8, IL-10, IFN-γ and related mediators (IL-6R, CXCR1/2, IL-10R, IFNGR)

This entry represents a heterogeneous group of cytokine receptors that play pivotal roles in orchestrating the immune response and inflammatory signaling. The Interleukin-6 receptor (IL-6R) and Interleukin-10 receptor (IL-10R) are members of the Type I and Type II cytokine receptor families, respectively, and primarily utilize the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway to regulate gene expression [PMID: 29080852]. The Interleukin-8 receptors (CXCR1 and CXCR2) are G protein-coupled receptors (GPCRs) that drive the recruitment and activation of neutrophils to sites of injury or infection [PMID: 30213465]. The Interferon-gamma receptor (IFNGR) is essential for activating macrophages and promoting Th1-type immune responses, making it a key player in antiviral and antitumor defense [PMID: 10359101]. Dysregulation of these receptor systems is a hallmark of various pathologies, including rheumatoid arthritis, cytokine release syndrome (CRS), and chronic inflammatory disorders. Consequently, they are major therapeutic targets for monoclonal antibodies, such as tocilizumab for IL-6R and emapalumab for IFN-gamma signaling, as well as small molecule inhibitors targeting their downstream signaling cascades [PMID: 32433942].

Other names

Interleukin-6 receptor (IL-6R)Interleukin-8 receptor (CXCR1/2)Interleukin-10 receptor (IL-10R)Interferon-gamma receptor (IFNGR)CD126CD181CD182CD210CD119gp130 (CD130)CXCR1CXCR2IFNGR1IFNGR2

Antagonism of ligand binding to cell-surface receptors, inhibition of receptor dimerization, and blockade of downstream Janus kinase (JAK) signaling pathways [PMID: 21113163, PMID: 32433942].