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Cytokine Regulation in Epithelial Cells
- Molecular classification
- Cytokine, Signaling molecule, Regulatory network
01
Overview
Cytokine regulation within epithelial tissues is a dynamic process essential for both normal physiology—such as wound healing—and pathophysiology—including allergy/asthma and chronic inflammatory states. The interplay between key alarmins like TSLP/IL–33/IL–25 with other pro-inflammatory/regulatory mediators orchestrates local immunity while providing promising therapeutic targets for intervention. It involves a complex network of signaling molecules (cytokines) produced by, and acting upon, epithelial cells, playing crucial roles in maintaining tissue homeostasis, orchestrating immune responses, mediating inflammation, and facilitating tissue repair.
02
Mechanism of action
Autocrine/paracrine/endocrine signaling via specific membrane-bound receptors, modulation of gene expression through pathways such as NF-kB, JAK/STAT, MAPK
03
Biological functions
Immune modulationTissue homeostasisWound healingInflammationCell proliferationApoptosisBarrier integrity regulation
04
Disease associations
AsthmaAllergic diseasesInflammatory bowel disease (IBD)Chronic inflammatory diseasesRhinitisEczema
05
Interacting drugs
Blocking antibodies against TSLP
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