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Target intelligence / Profile preview
Cytokine release
- Molecular classification
- Process
01
Overview
Cytokine release is the process by which immune cells secrete cytokines, leading to communication between cells during immune responses. Excessive or uncontrolled cytokine release results in a systemic inflammatory response known as a "cytokine storm" or Cytokine Release Syndrome (CRS), characterized by widespread inflammation and multi-organ dysfunction.
- Other names
- Cytokine stormCytokine Release Syndrome (CRS)Infusion reaction
02
Mechanism of action
Overstimulation of the immune system leading to excessive cytokine production and systemic inflammation.
03
Biological functions
Immune signalingInflammationCell communication
04
Disease associations
Systemic inflammatory response syndromeCRS (Cytokine Release Syndrome)InfectionComplication of immunotherapy
05
Safety considerations
Multi-organ dysfunctionHypotensionRespiratory distressNeurological toxicityPotential for life-threatening complications
06
Interacting drugs
ABECMA® (idecabtagene vicleucel)
10 more in the full profile.
07
Biomarkers
IFNγTNFαIL-6IL-1GM-CSF
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