Molecular Classification
Process
Other Names
Cytokine storm, Cytokine Release Syndrome (CRS), Infusion reaction
Disease Roles
Systemic inflammatory response syndromeCRS (Cytokine Release Syndrome)Infection

Cytokine release Overview

Cytokine release is the process by which immune cells secrete cytokines, leading to communication between cells during immune responses. Excessive or uncontrolled cytokine release results in a systemic inflammatory response known as a "cytokine storm" or Cytokine Release Syndrome (CRS), characterized by widespread inflammation and multi-organ dysfunction.

Mechanism of Action

Overstimulation of the immune system leading to excessive cytokine production and systemic inflammation.

Biological Functions

Immune signaling
Inflammation
Cell communication

Disease Associations

Systemic inflammatory response syndrome
CRS (Cytokine Release Syndrome)
Infection
Complication of immunotherapy

Safety Considerations

  • Multi-organ dysfunction
  • Hypotension
  • Respiratory distress
  • Neurological toxicity
  • Potential for life-threatening complications

Interacting Drugs

ABECMA® (idecabtagene vicleucel)
CARVYKTI®
ELREXFIO®
TALVEY™
TECVAYLI™
Rituximab
Obinutuzumab
Anti-thymocyte globulin
CD28 superagonist
Corticosteroids
Tocilizumab

Associated Biomarkers

Biomarker
IFNγ
TNFα
IL-6
IL-1
GM-CSF