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Target intelligence / Profile preview
Cytomegalovirus Antigen pp65 (pp65)
- Target
- pp65
- Molecular classification
- Viral protein, Tegument protein, Phosphoprotein
01
Overview
Cytomegalovirus antigen pp65 (pp65 or UL83) is the major structural protein of human cytomegalovirus (HCMV). It plays a key role in modulating host immune responses by inhibiting interferon production and participating in transactivation of viral genes. pp65 is an immunodominant antigen recognized by T cells, making it a valuable target for diagnostic assays, immune monitoring, and vaccine development, although it may not be sufficient as a single target for effective vaccine-induced immunity.
- Other names
- Phosphoprotein UL83Tegument Protein UL8365 kDa matrix phosphoproteinUL83
02
Biological functions
Immune evasionInhibition of IRF3Immediate early gene transactivationModulation of interferon response
03
Disease associations
Cytomegalovirus infectionInfection in immunocompromised patients
04
Safety considerations
Targeting pp65 alone may not provide full protection against HCMV
05
Biomarkers
pp65 antigenemia for CMV infection diagnosisCMV-specific T cell responses
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