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Target intelligence / Profile preview
Cytomegalovirus Antigens (CMV Antigens)
- Target
- CMV Antigens
- Molecular classification
- Viral Protein, Glycoprotein, Phosphoprotein, Tegument Protein, Envelope Protein, Immune Evasion Protein
01
Overview
Cytomegalovirus (CMV) antigens are viral proteins and glycoproteins expressed during the replication cycle of human cytomegalovirus (HCMV). These antigens are critical for viral structure, replication, immune evasion, and pathogenesis. They serve as targets for both humoral and cellular immune responses and are used extensively in diagnostic assays. Key examples include pp150, pp65, pp52, gB and US2, each playing distinct roles in viral infection and host-pathogen interactions. Some antigens like US2 actively downregulate MHC I presentation to evade immune detection.
- Other names
- HCMV Antigenspp150pp65pp52gB (glycoprotein B)pp38US2vCXCL1
02
Biological functions
Viral ReplicationImmune EvasionViral StructureAntibody BindingT Cell ActivationChemokine MimicryMHC-I downregulation
03
Disease associations
Cytomegalovirus InfectionCongenital CMV InfectionInfection in Immunocompromised IndividualsPost-transplant complications
04
Safety considerations
Risk of congenital CMV infectionReactivation in immunocompromised patientsDrug resistanceLack of licensed vaccine
05
Biomarkers
pp65 antigenemia (diagnosis)Anti-CMV antibodies (IgG, IgM - past/recent infection)Viral load (qPCR)T cell responses (ELISpot, flow cytometry)
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