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Cytomegalovirus DNA Polymerase (CMV DNA Polymerase)
- Target
- CMV DNA Polymerase
- Molecular classification
- Enzyme, DNA Polymerase
01
Overview
Cytomegalovirus (CMV) DNA polymerase is a viral enzyme essential for the replication of CMV. It is the primary target for several antiviral drugs used to treat CMV infections, particularly in immunocompromised patients. The enzyme consists of two main subunits: the catalytic subunit (UL54) and the accessory subunit (UL44). UL54 is responsible for DNA synthesis, while UL44 acts as a processivity factor. The CMV DNA polymerase is inhibited by antiviral agents like ganciclovir, foscarnet, and cidofovir, which are approved treatments against severe CMV disease. Resistance can develop through mutations primarily within functional regions under selective pressure from antiviral therapy.
- Other names
- HCMV DNA polymeraseUL54UL44
02
Mechanism of action
Inhibition of viral DNA polymerase activity.
03
Biological functions
Viral genome replicationDNA synthesis
04
Disease associations
InfectionCytomegalovirus infection
05
Safety considerations
Drug resistance due to mutations in UL54.Toxicity associated with antiviral agents (e.g., nephrotoxicity with cidofovir).
06
Interacting drugs
Ganciclovir
2 more in the full profile.
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