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Target intelligence / Profile preview
Cytomegalovirus DNA Terminase Complex Subunit pUL56 (pUL56)
- Target
- pUL56
- Molecular classification
- Enzyme, Terminase subunit, Viral protein
01
Overview
The cytomegalovirus DNA terminase complex subunit pUL56 is a key protein involved in the replication cycle of human cytomegalovirus (HCMV). It is a major component of the viral terminase complex, essential for packaging viral DNA into capsids during virion assembly. pUL56 recognizes and binds specific packaging motifs on viral DNA, acts as an "anchor" for other terminase subunits, facilitates translocation of viral DNA into preformed capsids, exhibits ATP-independent endonuclease activity, and provides ATP necessary for genome encapsidation. It is the primary target of the antiviral drug letermovir.
- Other names
- UL56 proteinHCMV pUL56UL56 gene product
02
Mechanism of action
Inhibition of the cytomegalovirus terminase complex, specifically through interaction with UL56/pUL56, thereby preventing viral DNA packaging and replication.
03
Biological functions
Viral DNA recognition and bindingATP generationInteraction with portal proteinViral genome packagingDNA translocationEndonuclease activity
04
Disease associations
InfectionHuman cytomegalovirus infection
05
Safety considerations
Resistance mutations to letermovir (amino acids 231–369)Potential for cross-resistance with other antivirals is low, but resistance to letermovir can develop.
06
Interacting drugs
Letermovir
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