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Target intelligence / Profile preview
Cytomegalovirus Glycoprotein Complexes (CMV Glycoprotein Complexes)
- Target
- CMV Glycoprotein Complexes
- Molecular classification
- Viral Glycoprotein Complex, Viral Fusion Protein, Type I transmembrane protein
01
Overview
Cytomegalovirus (CMV) encodes multiple envelope glycoproteins that assemble into distinct complexes on the viral surface. These complexes, including gB, gH/gL, gH/gL/gO, gH/gL/UL128-131, and gM/gN, are essential for viral entry, cell tropism, immune evasion, and pathogenesis. Targeting these complexes is a therapeutic strategy to prevent or treat CMV infections.
- Other names
- CMV Envelope GlycoproteinsHCMV Glycoprotein Complexes
02
Mechanism of action
Viral entry inhibition
03
Biological functions
Virus attachment to host cellsMembrane fusionCell-type specific entryImmune evasionVirion AssemblyCell-to-cell spread
04
Disease associations
InfectionCytomegalovirus Infection
05
Safety considerations
Potential for off-target effects on host glycoproteinsDevelopment of drug resistance
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