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Target intelligence / Profile preview
Cytomegalovirus-Infected Host Cell (HCMV-Infected Host Cell)
- Target
- HCMV-Infected Host Cell
- Molecular classification
- Cell, Infected Cell
01
Overview
A cytomegalovirus-infected host cell refers to any human cell that has been invaded and is actively manipulated by human cytomegalovirus (HCMV). HCMV can infect a wide variety of cell types, leading to various cellular and molecular changes that facilitate viral replication, immune evasion, and persistence. The infected cell undergoes metabolic reprogramming, cell cycle manipulation, and expresses viral factors that interfere with host immune responses.
- Other names
- HCMV-infected cellCMV-infected cellHost cell infected with cytomegalovirus
02
Mechanism of action
Antiviral drugs targeting viral DNA polymerase or terminase complex
03
Biological functions
Viral replicationViral disseminationImmune evasionMetabolic reprogrammingCell cycle manipulationLatency establishmentReactivation
04
Disease associations
Cytomegalovirus infectionCongenital CMV infectionCMV retinitisPneumonia (in immunocompromised individuals)Gastrointestinal disease (in immunocompromised individuals)Other opportunistic infections (in immunocompromised individuals)
05
Safety considerations
Drug resistanceNephrotoxicity (foscarnet, cidofovir)Myelosuppression (ganciclovir, valganciclovir)Teratogenicity (ganciclovir, valganciclovir)Drug-drug interactions
06
Interacting drugs
Ganciclovir
4 more in the full profile.
07
Biomarkers
CMV viral load (plasma, blood, other body fluids)CMV pp65 antigenemiaCMV DNA detection (PCR)Histopathology (detection of cytomegalic cells with "owl's eye" inclusions)
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