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Target intelligence / Profile preview
Cytomegalovirus matrix protein pp65 (pp65)
- Target
- pp65
- Molecular classification
- Viral protein, Herpesviridae pp65 family, Matrix protein, Tegument protein
01
Overview
The cytomegalovirus matrix protein pp65 is a major tegument protein of human cytomegalovirus (HCMV), encoded by the UL83 gene. It plays multiple roles in viral replication, immune evasion by inhibiting IRF3 and interferon production, and modulation of host cell processes through gene regulation.
- Other names
- Phosphoprotein UL83Tegument protein UL8365 kDa matrix phosphoprotein65 kDa phosphoprotein
02
Biological functions
Virion assemblyImmune evasionInterferon regulatory factor 3 (IRF3) inhibitionGene regulationTransactivation of major immediate early genesModulation of host cell processes
03
Disease associations
InfectionHCMV infection
04
Biomarkers
Immunodominant marker for monitoring cellular immune responses against CMV
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