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Target intelligence / Profile preview
Cytomegalovirus Pentamer Complex Protein (HCMV Pentamer)
- Target
- HCMV Pentamer
- Molecular classification
- Viral Glycoprotein Complex, Receptor Complex
01
Overview
The cytomegalovirus pentamer complex protein is a multi-subunit glycoprotein assembly crucial for human cytomegalovirus’s ability to infect diverse cell types beyond fibroblasts by engaging specific host receptors such as NRP2. Its structural complexity underpins its dual roles in mediating cell tropism/entry and modulating post-entry events during infection while serving as a dominant antigenic target shaping immune responses against CMV infections.
- Other names
- HCMV Pentamer ComplexPentamer ComplexgH/gL/UL128/UL130/UL131A complex
02
Mechanism of action
Viral entry inhibition (potential target for antiviral drugs)
03
Biological functions
Viral EntryCellular TropismImmune EvasionReceptor Binding
04
Disease associations
InfectionCytomegalovirus InfectionCongenital CMV Infection
05
Safety considerations
Off-target effects of drugs targeting viral entryPotential for drug resistance
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