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Cytomegalovirus phosphoprotein 65 (CMV pp65)

Target: CMV pp65
Molecular classification: Phosphoprotein, Viral Protein, Tegument protein

Overview

Cytomegalovirus phosphoprotein 65 (pp65) is a major structural and immunodominant protein of the human cytomegalovirus (HCMV). It is a tegument protein and one of the most abundantly produced proteins in HCMV virions. pp65 elicits strong CD4+ and CD8+ T cell responses in seropositive individuals. It is being explored as a target for adoptive T-cell therapies, especially in glioblastoma multiforme (GBM), where it serves as a tumor-specific antigen.

Other names: pp65UL83 protein

Mechanism of action

Induction of T-cell mediated cytotoxicity

Biological functions

Structural supportImmunomodulationViral dissemination

Disease associations

InfectionGlioblastoma multiforme (GBM)

Safety considerations

Potential for off-target effects in adoptive T-cell therapiesRisk of inducing excessive immune response

Biomarkers

CMV pp65 expression levelCMV-specific T cell response

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