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Cytomegalovirus phosphoprotein pp65 (None)
- Target
- None
- Molecular classification
- Herpesviridae pp65 family, Phosphoprotein, Tegument protein
01
Overview
Cytomegalovirus phosphoprotein pp65, encoded by the UL83 gene, is a major structural and immunodominant protein of human cytomegalovirus (HCMV). It is located in the viral tegument and plays a critical role in immune evasion by inhibiting the host's antiviral interferon response through mechanisms like preventing IRF3 from entering the nucleus and inactivating cGAS. pp65 also contributes to the transactivation of viral immediate early genes. Its strong immunogenicity makes it a target for T cell responses and antibody detection, and it is widely used in research and diagnostics related to HCMV infection.
- Other names
- UL8365 kDa phosphoproteinMatrix phosphoproteinTegument protein UL83
02
Mechanism of action
Inhibition of IRF3 nuclear translocation; Inactivation of cGAS
03
Biological functions
Immune evasionIRF3 inhibitionType I interferon suppressionTransactivation of viral genesModulation of host immune response
04
Disease associations
InfectionCytomegalovirus infection
05
Safety considerations
Potential for immune escape with targeted therapies
06
Biomarkers
T cell response to pp65 peptidesAntibody levels against pp65
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