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Target intelligence / Profile preview
Cytomegalovirus pp65 protein (pp65)
- Target
- pp65
- Molecular classification
- Viral Protein, Tegument Protein, Herpesviridae pp65 family
01
Overview
The cytomegalovirus pp65 protein (UL83) is a major structural and tegument protein of Human cytomegalovirus (HCMV). It plays critical roles in immune evasion by inhibiting interferon responses, tegument assembly during virion morphogenesis, and transactivation of viral genes. pp65 is a major target for cellular and humoral immune responses and is widely used in diagnostic assays. While dispensable for replication in fibroblasts, it is essential for efficient growth in monocyte-derived macrophages. Targeting pp65 is an area of focus for developing immunotherapies and antiviral strategies against HCMV.
- Other names
- UL8365 kDa phosphoproteinmatrix phosphoproteinPhosphoprotein UL83Tegument protein UL83
02
Mechanism of action
Not applicable as a drug target directly, but inhibition of its function or targeting it with antibodies are potential therapeutic strategies.
03
Biological functions
Immune evasionTegument assemblyTransactivationViral replication
04
Disease associations
InfectionHuman Cytomegalovirus (HCMV) infection
05
Safety considerations
Potential for immune evasion mutationsOff-target effects of immune-based therapies
06
Biomarkers
pp65 mRNApp65 antigenemia
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