Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cytomegalovirus protein kinase (UL97)
- Target
- UL97
- Molecular classification
- Enzyme, Serine/threonine protein kinase, Viral kinase
01
Overview
The cytomegalovirus protein kinase, UL97, is a serine/threonine protein kinase encoded by the human cytomegalovirus (HCMV) genome. It plays essential roles in viral replication and modulation of host cell processes during infection. It phosphorylates ganciclovir for activation, and also phosphorylates several key cellular proteins. Loss or inhibition results in defective secondary envelopment steps during virion assembly.
- Other names
- pUL97
02
Mechanism of action
Ganciclovir: Phosphorylation and activation by UL97 leading to inhibition of viral DNA polymerase. Maribavir: Inhibition of UL97 kinase activity.
03
Biological functions
Viral DNA replication regulationCapsid egress & assemblyPhosphorylation of antiviral drugsModulation of host cell processes
04
Disease associations
Infection
05
Safety considerations
Drug resistance due to mutations in UL97
06
Interacting drugs
Ganciclovir
1 more in the full profile.
Beyond the preview
Go deeper on Cytomegalovirus protein kinase (UL97).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cytomegalovirus protein kinase (UL97).