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Target intelligence / Profile preview
Cytomegalovirus Terminase Complex Subunit pUL56 (pUL56)
- Target
- pUL56
- Molecular classification
- Enzyme, ATPase, Viral protein, Terminase subunit
01
Overview
pUL56 is a key subunit of the human cytomegalovirus (HCMV) terminase complex, essential for viral DNA maturation and packaging. It functions as an ATPase and DNA-binding protein, anchoring the terminase complex to viral DNA and providing energy for DNA translocation into capsids. It interacts directly with pUL89 and pUL104. As its structure is unique to herpesviruses, pUL56 represents an attractive target for antiviral therapy; the drug letermovir inhibits HCMV replication by targeting this protein. Resistance mutations have been mapped to the UL51, UL56, and UL89 genes.
- Other names
- UL56 proteinHCMV pUL56UL56 gene product
02
Mechanism of action
Inhibition of viral DNA packaging by targeting the terminase complex.
03
Biological functions
Viral DNA bindingATP hydrolysisViral genome packagingTerminase complex assemblyViral DNA translocation
04
Disease associations
InfectionCytomegalovirus infection
05
Safety considerations
Development of resistance mutations
06
Interacting drugs
Letermovir
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