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Target intelligence / Profile preview
Cytoplasmic deoxycytidine kinase (dCK)
- Target
- dCK
- Molecular classification
- Enzyme, Kinase
01
Overview
Cytoplasmic deoxycytidine kinase (dCK) is a cytoplasmic enzyme that catalyzes the phosphorylation of deoxycytidine (dC), deoxyadenosine (dA), and deoxyguanosine (dG), as well as their nucleoside analogs. It is a key enzyme in the nucleoside salvage pathway, recycling preformed nucleosides for DNA synthesis. dCK plays a role in maintaining balanced pools of DNA precursors, DNA repair, and apoptosis. It also activates various therapeutic nucleoside analogs used in cancer chemotherapy and antiviral treatments. Inhibitors targeting dCK are being explored therapeutically to modulate its activity.
02
Mechanism of action
Phosphorylation of deoxyribonucleosides and nucleoside analogs, activation of prodrugs
03
Biological functions
Nucleotide salvage pathwayDNA synthesisDNA repairRegulation of dNTP poolsApoptosis
04
Disease associations
CancerAutoimmune diseasesViral infections
05
Safety considerations
Drug resistanceToxicity of chemotherapies
06
Interacting drugs
Anticancer nucleoside analogs
2 more in the full profile.
07
Biomarkers
dCK expression levelsdCK activity
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