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Target intelligence / Profile preview
Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2)
- Target
- DYNC1I2
- Molecular classification
- Other (Microtubule motor protein component)
01
Overview
Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) is a non-catalytic accessory subunit of the cytoplasmic dynein 1 complex, which functions as a major microtubule motor responsible for intracellular retrograde transport of various cargos, including organelles and vesicles, along microtubules. DYNC1I2 is essential for dynein complex assembly, cargo adaptor binding, and regulation of motor function. It is ubiquitously expressed across numerous tissues and contributes to processes such as mitotic spindle assembly and chromosome segregation[3][4][2][1][6]. This protein does not serve as a classical therapeutic target (such as a receptor, ion channel, or enzyme), and there are currently no approved drugs known to act selectively on DYNC1I2. However, genetic alterations in DYNC1I2 may be relevant to basic research in cell division and neurobiology.
- Other names
- Cytoplasmic dynein 1 intermediate chain 2DYNC1I2DNCI2DNCIC2DH IC-2DIC74IC2NEDMIBAtestis tissue sperm-binding protein Li 66n
02
Biological functions
Microtubule-based transportCytoskeletal organizationCargo binding and linkage to dynein complex
03
Disease associations
Other (Potential role in neurodevelopmental and cell division disorders; no established direct disease association)
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