Cytoplasmic polyadenylation element-binding protein 1 (CPEB1)

Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is a highly conserved, sequence-specific RNA-binding protein that regulates translation and stability of mRNAs by binding to uridine-rich cytoplasmic polyadenylation elements (CPEs) in the 3' UTR of target transcripts. CPEB1 controls poly(A) tail elongation (to enable translation) and represses or activates translation in a phosphorylation-dependent manner, thereby regulating essential biological processes such as cell cycle progression, oocyte maturation, stem cell activation, synaptic plasticity, and formation of stress granules. Dysfunction or altered regulation of CPEB1 is associated with cancer, neurodegenerative diseases, and infertility, making it a potential therapeutic target.

Other names

CPEB1CPEBCPE-BP1CPE-binding protein 1h-CPEBhCPEB-1FLJ13203

Drugs or small molecules targeting CPEB1 would be expected to modulate its RNA-binding activity or its phosphorylation state, thereby altering translation of CPE-containing mRNAs and affecting cellular proliferation, differentiation, or plasticity.