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Cytosine Permease (Fungal)

Molecular classification: Transporter

Overview

Cytosine permease is an enzyme responsible for transporting cytosine and related compounds, such as 5-flucytosine (5-FC), into fungal cells. This transport is crucial for the action of antifungal drugs like flucytosine, which is metabolized inside the fungal cell to exert its antifungal effects. Resistance to 5-flucytosine can arise from mutations affecting cytosine permease or other enzymes involved in its metabolic pathway.

Mechanism of action

Facilitates the entry of 5-flucytosine into fungal cells, enabling its conversion to 5-fluorouracil, which disrupts DNA and RNA synthesis.

Biological functions

Transport of cytosine and related compounds

Disease associations

Infection

Safety considerations

Development of resistance due to mutations in cytosine permease or related enzymes

Interacting drugs

Flucytosine

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