Cytoskeleton-associated protein 2-like (CKAP2L)

Cytoskeleton-associated protein 2-like (CKAP2L) is a microtubule-associated protein essential for organizing the mitotic spindle and promoting proper cell-cycle progression in neural progenitor cells[1][2][3][4][6]. CKAP2L (also called Radmis) localizes to mitotic spindles and radial fibers during cell division, ensuring microtubule stability and accurate chromosome segregation[4][6]. Loss-of-function mutations in CKAP2L cause Filippi syndrome, a rare congenital disorder involving microcephaly, syndactyly, growth retardation, and intellectual disability, by disrupting neural stem/progenitor cell mitosis[1][2][3][4][6]. CKAP2L is also implicated in tumorigenesis, with overexpression linked to cell proliferation and progression in several cancer types[4]. This protein is not currently an established therapeutic target, and there are no drugs or chemical inhibitors specifically known to target CKAP2L.

Other names

CKAP2LRadmisFLJ40629Radial fiber and mitotic spindle proteincytoskeleton-associated protein 2-likeradial fiber and mitotic spindle protein