Cytoskeleton-associated protein 4 (CKAP4)

Cytoskeleton-associated protein 4 (CKAP4) is a multifunctional type II transmembrane protein primarily located in the rough endoplasmic reticulum (ER) but also found at the plasma membrane where it can function as a ligand-activated receptor, notably for DKK1[2][4]. CKAP4 mediates the anchoring of the ER to microtubules and thus organizes the overall structure of the ER within the cell[5][6]. It plays key roles in cell proliferation, migration, and signal transduction and has been implicated in tumorigenesis, with its expression correlating with prognosis in certain cancers such as hepatocellular carcinoma. CKAP4 is emerging as a promising cancer biomarker and potential therapeutic target, although its dual role in both tumor promotion and suppression, depending on context and specific ligand interactions, indicates a need for cautious therapeutic exploration[2][3][4].

Other names

CLIMP-63Cytoskeleton-linking membrane protein 63p63

Acts as a cell surface receptor for DKK1, activating PI3K-Akt signaling pathway leading to cell proliferation[4]; Anchors rough ER to microtubules, organizing ER and participating in intracellular trafficking and signaling[2][5][6].