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Target intelligence / Profile preview
Puromycin-sensitive aminopeptidase (PSA)
- Target
- PSA
- Molecular classification
- Enzyme, Metallopeptidase, Zinc metallopeptidase
01
Overview
Puromycin-sensitive aminopeptidase (PSA), also known as cytosol alanyl aminopeptidase or alanine aminopeptidase (AAP), is a zinc-dependent metallopeptidase encoded by the NPEPPS gene in humans. It plays a key role in degrading neuroactive peptides and is involved in the final steps of intracellular peptide hydrolysis. Elevated levels are detected in urine during kidney damage. Upregulation has been observed in platinum-resistant bladder cancer cells, and inhibition sensitizes tumors to cisplatin.
- Other names
- Cytosol alanyl aminopeptidaseAlanine aminopeptidase (AAP)AAP-SMP100
02
Mechanism of action
Inhibition of N-terminal amino acid removal from peptides, Sensitizes tumors to cisplatin
03
Biological functions
Peptide hydrolysisNeuroactive peptide degradationIntracellular peptide hydrolysisPolyglutamine sequence digestion
04
Disease associations
Kidney injuryNeurodegenerative diseaseCancerAlzheimer's disease
05
Safety considerations
Inhibition can exacerbate tau-induced neurodegeneration
06
Interacting drugs
Puromycin
1 more in the full profile.
07
Biomarkers
Elevated urine levels in kidney damage
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