Cytosolic carboxypeptidase 2 (AGBL2)

Cytosolic carboxypeptidase 2 (AGBL2) is a metallocarboxypeptidase enzyme that catalyzes deglutamylation—a process of removing polyglutamate side chains from the C-terminal tail of tubulin and other non-tubulin proteins. This activity regulates microtubule stability and function within cells. Disruption or aberrant activity of AGBL2 has been linked to diseases such as certain cancers (notably hepatocellular carcinoma) and rare rheumatologic and developmental syndromes. Subcellular localization studies indicate that AGBL2 is found in centrioles and the ciliary basal body, implicating it in cytoskeletal and ciliary functions.

Other names

AGBL2Carboxypeptidase 2CCP2FLJ23598ATP/GTP-binding protein-like 2Protein deglutamylase CCP2Cytoplasmic carboxypeptidase 2Testis tissue sperm-binding protein Li 96mP

Catalytic removal of polyglutamate side chains from target proteins, especially tubulin; drugs would likely act via inhibition or modulation of enzymatic activity, but no drug MOA documented