Cytosolic carboxypeptidase 4 (AGBL1)

Cytosolic carboxypeptidase 4 (AGBL1) is a metallocarboxypeptidase enzyme that catalyzes the removal of polyglutamate side chains from glutamate residues at the C-terminal tail of tubulin and other non-tubulin proteins, a process critical for regulating protein function through reversible polyglutamylation. Mutations in AGBL1 are associated with dominant late-onset Fuchs corneal dystrophy, implicating it in ocular disease pathogenesis. The enzyme participates in protein modification pathways with roles in protein–protein interactions and cellular metabolism[1][9].

Other names

Cytosolic carboxypeptidase 4CCP4ATP/GTP-binding protein-like 1Protein deglutamylase CCP4FECD8

Catalysis of deglutamylation; specifically, removal of polyglutamate side chains from the C-terminus of tubulin and non-tubulin proteins[1][9].