Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2)

NUBP2 (Cytosolic Fe-S cluster assembly factor NUBP2) is an ATP- and metal-binding protein required for the biogenesis and maturation of extramitochondrial (mainly cytosolic and nuclear) iron-sulfur (Fe-S) cluster-containing proteins in mammalian cells[1][3][7]. It forms a heterotetrameric scaffold complex with its paralog NUBP1, mediating de novo assembly of Fe-S clusters for transfer to target apoproteins[7]. NUBP2 belongs to the NUBP/MRP subfamily of P-loop NTPases and has homology to cell division proteins in prokaryotes[3][4]. Mutations or disruptions in NUBP2 impair Fe-S protein maturation, affecting numerous cellular processes that depend on functional Fe-S clusters, and are associated with certain neurodegenerative diseases[7]. There are no established direct drug interactions or biomarker applications. NUBP2 is not considered a conventional therapeutic target such as a receptor, enzyme, or transporter, but is critical for basic cellular iron-sulfur metabolism and protein assembly[7].

Other names

Nucleotide-binding protein 2NBP 2CFD1CIAO6NUBP iron-sulfur cluster assembly factor 2NUBP1 (note: NUBP1 is a closely related but distinct paralog)cytosolic Fe-S cluster assembly factor NUBP2MinD homolog (E. coli)homolog of yeast cytosolic Fe-S cluster deficient 1