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Cytosolic iron-sulfur assembly component 2A (CIAO2A)
- Target
- CIAO2A
- Molecular classification
- Other (component of cytosolic iron-sulfur assembly complex; not a receptor, enzyme, or transporter)
01
Overview
Cytosolic iron-sulfur assembly component 2A (CIAO2A) is a protein involved in the assembly and incorporation of iron-sulfur (Fe-S) clusters into target cytosolic and nuclear proteins via the cytosolic iron-sulfur protein assembly (CIA) complex. It is predicted to enable metal ion binding activity, contributes to protein maturation by Fe-S cluster transfer, and localizes to the cytosol and nucleoplasm. CIAO2A is classified as a non-enzymatic, non-receptor, non-transporter protein, and is not considered a primary therapeutic target[1][2][5][9].
- Other names
- FAM96AFLJ22875CIA2AMIP18 family protein FAM96Afamily with sequence similarity 96 member A
02
Biological functions
Iron-sulfur cluster assemblyProtein maturation by iron-sulfur cluster transferMetal ion binding
03
Disease associations
Other (literature reports suggest a role in apoptosis regulation, but no direct established relevance as therapeutic target in major disease classes)
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