Cytosolic iron-sulfur assembly component 2B (CIAO2B)

Cytosolic iron-sulfur assembly component 2B (CIAO2B) is a protein that is a central component of the cytosolic iron–sulfur (Fe–S) assembly (CIA) complex, also called the CIA targeting complex (CTC). CIAO2B acts as an essential scaffold subunit that bridges CIAO1 and the client adaptor protein MMS19, facilitating the insertion of Fe–S clusters into target cytosolic and nuclear proteins, many of which are key DNA replication and repair enzymes[1][3][4]. CIAO2B is predicted (in mouse and rat) to be involved in protein maturation, chromosome segregation, and localizes primarily in the cytosol, nucleoplasm, and spindle apparatus[2][5]. There is currently no evidence for pharmacological inhibitors, drugs, or established biomarker utility for this molecule. Dysfunction of the CIA complex, including loss of CIAO2B, may compromise genome integrity and is linked to defects in DNA metabolism, with implications for cancer and other diseases where Fe–S cluster maturation is critical[1][4]. Note: CIAO2B is not a receptor, enzyme, transporter, or conventional therapeutic target but is an essential protein for proper assembly and function of Fe–S cluster-containing proteins in the cytosol and nucleus. No known drugs target it directly, nor is it commonly used as a biomarker.

Other names

CIABFAM96BMIP18CGI-128HSPC118CIA2BMSS19-interacting protein of 18 kDaMitotic spindle-associated MMXD complex subunit MIP18Protein FAM96Bfamily with sequence similarity 96 member B