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Target intelligence / Profile preview
Cytosolic Phospholipase A2 Alpha (cPLA2α)
- Target
- cPLA2α
- Molecular classification
- Enzyme, Phospholipase
01
Overview
Cytosolic phospholipase A₂ alpha (cPLA₂α) is an essential enzyme regulating membrane lipid metabolism with broad implications for inflammatory signaling pathways. Its unique structure enables precise regulation via calcium signals and kinase-mediated phosphorylation. As both a key initiator of eicosanoid biosynthesis and an important player in disease pathogenesis—including chronic inflammation, cancer progression, cardiovascular disorders, and viral infections—cPLA₂α remains an attractive target for therapeutic intervention despite challenges related to inhibitor specificity.
- Other names
- Group IVA phospholipase A2PLA2G4A
02
Mechanism of action
Inhibition of arachidonic acid release
03
Biological functions
Lipid metabolismEicosanoid synthesisInflammatory signalingCell proliferationCell migrationEndothelial function
04
Disease associations
InflammationCancerCardiovascular diseaseViral infection
05
Safety considerations
Off-target effects due to similarity with other PLA2 isoformsChallenges in achieving specificity with inhibitors
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