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Target intelligence / Profile preview
Cytotoxic T Lymphocyte Associated Antigen 4 (CTLA-4)
- Target
- CTLA-4
- Molecular classification
- Immunoglobulin superfamily, Receptor, CD28 family member, Transmembrane glycoprotein
01
Overview
Cytotoxic T lymphocyte associated antigen 4 (CTLA-4), also known as CD152, is a critical immune checkpoint receptor that plays a central role in regulating T cell-mediated immune responses and maintaining self-tolerance. It acts as a negative regulator of immune activation by binding to CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, inhibiting further T cell activation.
- Other names
- CD152
02
Mechanism of action
Blocking antibodies enhance antitumor immunity by promoting effector function while depleting intratumoral regulatory populations via mechanisms including antibody-dependent cellular cytotoxicity (ADCC).
03
Biological functions
Immune responseNegative regulation of T cell activationMaintenance of self-toleranceT cell regulationCheckpoint inhibition
04
Disease associations
Autoimmune diseasesCancer
05
Safety considerations
Immune-related adverse events (irAEs) due to excessive immune activation
06
Interacting drugs
Ipilimumab
1 more in the full profile.
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