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Target intelligence / Profile preview
Cytotoxic T lymphocyte associated protein 4 (CTLA-4)
- Target
- CTLA-4
- Molecular classification
- Receptor, Transmembrane glycoprotein, Immune Checkpoint
01
Overview
Cytotoxic T lymphocyte associated protein 4 (CTLA-4), also known as CD152, is a critical immune checkpoint receptor expressed primarily on activated T cells and regulatory T cells (Tregs). It plays a central role in downregulating immune responses and maintaining self-tolerance by acting as a negative regulator of T cell-mediated immunity.
- Other names
- CD152
02
Mechanism of action
Inhibition of CTLA-4, blocking its interaction with B7 ligands (CD80/CD86)
03
Biological functions
Immune responseNegative regulation of T cell-mediated immunityMaintenance of self-toleranceT cell inhibition
04
Disease associations
Autoimmune diseasesCancer
05
Safety considerations
Immune-related adverse events (irAEs) due to immune dysregulation and autoimmunity
06
Interacting drugs
Ipilimumab
1 more in the full profile.
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