D-2-hydroxy-acid dehydrogenase

The term **“UD-2-hydroxyacid dehydrogenase” appears to be incorrect or non‑standard; no enzyme, receptor, or therapeutic target with the exact name “UD-2-hydroxyacid dehydrogenase” is described in the biochemical or structural literature, and it is not recognized in enzymatic classifications. Instead, the closest valid concept is the **enzyme family “D‑2‑hydroxy‑acid dehydrogenases” (EC 1.1.99.6)**, commonly called **D‑2‑hydroxyacid dehydrogenase** or **D‑2‑hydroxy-acid dehydrogenases** in the plural when referring to the family.[4][6] These enzymes catalyze the **stereospecific, reversible oxidation–reduction between D‑configured 2‑hydroxyacids and the corresponding 2‑ketoacids**, using electron acceptors such as NAD(H) or other acceptors depending on the specific enzyme.[4][6] They are **metabolic enzymes**, not receptors or classical drug targets, and are mainly studied for their role in central metabolism and in biocatalysis rather than as therapeutic targets. Structural and mechanistic work shows that members of this family typically belong to the **NAD(H)-dependent 2‑hydroxyacid dehydrogenase superfamily**, often adopting Rossmann‑fold–type domains for nucleotide binding and harboring conserved active‑site residues that mediate substrate recognition and proton/hydride transfer during catalysis.[2][6][7] Because the supplied name includes an unexplained leading “U” (“UD‑2‑hydroxyacid dehydrogenase”), and no such specific protein or gene can be matched in curated databases or the literature, this entry is best treated as a **misnamed or insufficiently specified reference to the broader D‑2‑hydroxy‑acid dehydrogenase enzyme family**, rather than to a single, druggable molecular target.[4][6]

Other names

D-2-hydroxyacid dehydrogenaseD-2-hydroxy-acid dehydrogenases (enzyme family)D-2-hydroxyacid dehydrogenases (enzyme family)D-2-HydDH (family abbreviation)