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Target intelligence / Profile preview
D-Alanine-D-Alanine Ligase (Ddl)
- Target
- Ddl
- Molecular classification
- Enzyme, Ligase, ATP-grasp ligase, Acid-D-amino-acid ligase, Peptide synthase
01
Overview
D-Ala-D-Ala ligase (Ddl) is an essential bacterial enzyme that catalyzes the ATP-dependent condensation of two D-alanine molecules to form the dipeptide D-alanyl-D-alanine. This dipeptide is a critical building block for peptidoglycan, a vital component of the bacterial cell wall. Due to its essential role in bacteria but absence from humans, this enzyme is a validated target for antibiotic development. Inhibiting this enzyme disrupts cell wall synthesis leading to bacterial death.
- Other names
- Alanine:alanine ligase (ADP-forming)Alanylalanine synthetaseD-alanine:D-alanine ligase (ADP-forming)
02
Mechanism of action
Inhibition of D-Ala-D-Ala ligase, disrupting peptidoglycan biosynthesis and cell wall formation.
03
Biological functions
Peptidoglycan biosynthesisCell wall assemblyBacterial cell wall formationCell wall precursor synthesis
04
Disease associations
Infection
05
Interacting drugs
D-cycloserine
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