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Target intelligence / Profile preview
DD-Transpeptidase
- Molecular classification
- Enzyme, Peptidase, Penicillin-binding protein
01
Overview
DD-transpeptidase is a bacterial enzyme essential for peptidoglycan biosynthesis, catalyzing the cross-linking of peptide side chains in the bacterial cell wall. It is a target for β-lactam antibiotics, which inhibit its activity and disrupt cell wall synthesis, leading to bacterial cell death or stasis.
- Other names
- DD-peptidaseD-alanyl-D-alanine carboxypeptidaseSerine-type D-Ala-D-Ala carboxypeptidasePenicillin-binding proteins (PBPs)
02
Mechanism of action
β-lactam antibiotics irreversibly acylate the active site serine residue, blocking enzymatic activity required for cell wall synthesis.
03
Biological functions
Peptidoglycan biosynthesisCell wall synthesisTranspeptidationDD-transpeptidase activityDD-carboxypeptidase activity
04
Disease associations
InfectionBacterial infectionsAntibiotic resistance
05
Safety considerations
Antibiotic resistanceDevelopment of resistant bacterial strainsPotential for allergic reactions to β-lactam antibiotics
06
Interacting drugs
Penicillins
2 more in the full profile.
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