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Target intelligence / Profile preview
D-alanyl-D-alanine carboxypeptidase DacA
- Molecular classification
- Enzyme, Serine-type DD-carboxypeptidase, Penicillin-binding protein
01
Overview
D-alanyl-D-alanine carboxypeptidase DacA, also known as penicillin-binding protein 5 (PBP5), is a membrane-bound, penicillin-sensitive enzyme involved in bacterial cell wall synthesis. It specifically trims the C-terminal D-alanyl residues from peptidoglycan pentapeptides during the final stages of peptidoglycan biosynthesis. This activity is crucial for proper cell wall maturation and regulation of cell shape. It is a key target for beta-lactam antibiotics, and mutations can lead to antibiotic resistance.
- Other names
- Penicillin-binding protein 5 (PBP5)DD-carboxypeptidaseDD-peptidaseSerine-type D-Ala-D-Ala carboxypeptidases
02
Mechanism of action
Beta-lactam antibiotics bind covalently to PBPs like DacA, leading to enzyme deactivation and ultimately bacterial death due to defective cell wall synthesis.
03
Biological functions
Peptidoglycan synthesisCell wall biosynthesisCarboxypeptidationTranspeptidationRegulation of cell shape
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistance development
06
Interacting drugs
Penicillins
1 more in the full profile.
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