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Target intelligence / Profile preview
D-Alanyl-D-Alanine-containing Peptidoglycan Precursor
- Molecular classification
- Peptidoglycan, Bacterial cell wall component
01
Overview
The D-Ala-D-Ala-containing peptidoglycan precursor is a key molecular structure in bacterial cell wall biosynthesis. It refers specifically to the terminal dipeptide sequence (D-alanyl-D-alanine) found at the end of the pentapeptide stem attached to N-acetylmuramic acid (MurNAc) within peptidoglycan precursors, such as Lipid II. This motif is essential for cross-linking reactions that provide strength and rigidity to bacterial cell walls, and is a target for several antibiotics.
02
Mechanism of action
Inhibition of cell wall synthesis by preventing cross-linking of peptidoglycan
03
Biological functions
Cell wall synthesisSubstrate for transpeptidasesBacterial structural integrity
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance
06
Interacting drugs
Penicillins
2 more in the full profile.
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