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Target intelligence / Profile preview
D-alanyl-D-alanine carboxypeptidase DacB (DacB)
- Target
- DacB
- Molecular classification
- Enzyme, Peptidase_S13
01
Overview
D-alanyl-D-alanine carboxypeptidase DacB (PBP4) is an enzyme crucial for bacterial cell wall biogenesis. It functions as a DD-carboxypeptidase and DD-endopeptidase, removing C-terminal D-alanyl residues from peptidoglycan precursors. This activity is essential for proper peptidoglycan maturation and regulation of cross-linking within the bacterial cell wall. DacB is a penicillin-binding protein and a target for antibacterial drug development.
- Other names
- Penicillin-binding protein 4 (PBP4)DD-carboxypeptidaseDD-endopeptidaseD-alanyl-D-alanine endopeptidase
02
Mechanism of action
Inhibition of DD-carboxypeptidase activity, leading to disruption of peptidoglycan synthesis.
03
Biological functions
Cell wall biogenesisPeptidoglycan maturationPeptidoglycan remodelingRegulation of peptidoglycan cross-linking
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Potential for contributing to antibiotic resistance when inhibited.
06
Interacting drugs
Beta-lactam antibiotics (e.g., Penicillin)
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