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D-alanyl-D-alanine Synthetase (D-Ala:D-Ala ligase)
- Target
- D-Ala:D-Ala ligase
- Molecular classification
- Enzyme, Ligase, ATP-grasp ligase, Acid-D-amino-acid ligase, Peptide synthase
01
Overview
D-alanyl-D-alanine synthetase (D-alanine--D-alanine ligase) is an essential bacterial enzyme that catalyzes the ATP-dependent formation of the dipeptide D-Ala–D-Ala from two molecules of D-alanine. This reaction is a critical step in peptidoglycan biosynthesis, which is fundamental for bacterial cell wall integrity and survival. Because of its universal and essential function in bacteria—and absence in humans—it represents an attractive target for antibiotic development.
- Other names
- D-alanine--D-alanine ligaseAlanine:alanine ligase (ADP-forming)Alanylalanine synthetase
02
Mechanism of action
Inhibition of peptidoglycan synthesis, leading to bactericidal effects. D-cycloserine acts via formation of a phosphorylated adduct within the active site that mimics reaction intermediates and blocks enzymatic activity.
03
Biological functions
Peptidoglycan biosynthesisCell wall assemblyCell wall integrity
04
Disease associations
Infection
05
Safety considerations
Disruption of peptidoglycan synthesis.
06
Interacting drugs
D-cycloserine
1 more in the full profile.
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