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Target intelligence / Profile preview
D-amino acid oxidase (DAAO)
- Target
- DAAO
- Molecular classification
- Enzyme, Flavoenzyme, Oxidoreductase
01
Overview
D-Amino acid oxidase (DAAO) is a flavoenzyme that catalyzes the oxidative deamination of D-amino acids into their corresponding α-keto acids, ammonia, and hydrogen peroxide. It plays a crucial role in regulating D-serine levels in the brain, which modulates NMDA receptor activity. Dysregulation of DAAO has been implicated in neurological disorders like schizophrenia, making it a potential therapeutic target.
- Other names
- D-amino acid oxidaseD-AAOD-amino acid oxygen oxidoreductase
02
Mechanism of action
Inhibition of DAAO leading to increased D-serine levels at NMDA receptors.
03
Biological functions
D-amino acid catabolismD-serine regulationNMDA receptor modulationDetoxification
04
Disease associations
Neurological disordersSchizophrenia
05
Safety considerations
Potential for disrupting amino acid balanceEffects on NMDA receptor function need careful monitoring
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